Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention als...
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Main Authors | , , , , , , , , , , , , |
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Format | Patent |
Language | English Hebrew |
Published |
01.03.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and these compounds for use in therapy. |
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Bibliography: | Application Number: IL20220298983 |