Anti-viral central memory cd8+ veto cells in haploidentical stem cell transplantation

Methods of generating an isolated population of non-graft versus host disease (GVHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transpl...

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Main Authors Rakefet SIDLIK MUSKATEL, Rotem GIDRON BUDOVSKY, ESTHER BACHAR-LUSTIG, ASSAF LASK, YAIR REISNER, NOGA OR-GEVA
Format Patent
LanguageEnglish
Hebrew
Published 01.04.2022
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Summary:Methods of generating an isolated population of non-graft versus host disease (GVHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation, are disclosed. Cells generated by the methods, pharmaceutical compositions and methods of treatment are also disclosed.
Bibliography:Application Number: IL20220290337