Nanoparticle with single site for template polynucleotide attachment

Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from one or more scaffold DNA molecules and one o...

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Main Authors LAFRANCONI Pietro Gatti, BERTI Lorenzo, ROGERT BACIGALUPO Maria Candelaria, HOWARD Michael, YANG Xiangyuan, VINCENT Ludovic, BROWN Andrew A, LESSARD-VIGER Mathieu, BOWEN M. Shane, SHEN Fei, TEO Yin Nah, BENICE Olivia, NIRANTAR Saurabh, STORMS Lena, BRUSTAD Eric, BOUTELL Jonathan Mark, NEMIROSKI Alex, GEORGE Wayne N, MCDONALD Seth, PEISAJOVICH Sergio, BRODIN Jeffrey
Format Patent
LanguageEnglish
Hebrew
Published 01.02.2022
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Summary:Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from one or more scaffold DNA molecules and one or more scaffold polypeptides, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.
Bibliography:Application Number: IL20210289230