Immolative cell-penetrating complexes for nucleic acid delivery to the lung

There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides an...

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Main Authors HAABETH Ole Audun Werner, MCCLELLAN Rebecca, LEVY Ronald, BLAKE Tim R, WENDER Paul, WAYMOUTH Robert M, SALLETS Adrienne
Format Patent
LanguageEnglish
Hebrew
Published 30.09.2021
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Summary:There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into lung cells and lung tissue, both in vitro and in vivo.
Bibliography:Application Number: IL20210285206