A sirpalpha-41bbl fusion protein and methods of use thereof

SIRPlalpha-4lBBL fusion proteins are provided. Accordingly, there is provided a SIRPalpha-4lBBL fusion protein comprising a single amino acid linker between the SIRPalpha and the 41BBL. Also there is provided a SIRPalpha-4lBBL fusion protein in a form of at least a homo-trimer. Also provided are pol...

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Bibliographic Details
Main Authors YOSI GOZLAN, MICHAL DRANITZKI ELHALEL, Ido KAMINSKY, NOAM SHANI, Edwin BREMER
Format Patent
LanguageEnglish
Hebrew
Published 01.01.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:SIRPlalpha-4lBBL fusion proteins are provided. Accordingly, there is provided a SIRPalpha-4lBBL fusion protein comprising a single amino acid linker between the SIRPalpha and the 41BBL. Also there is provided a SIRPalpha-4lBBL fusion protein in a form of at least a homo-trimer. Also provided are polynucleotides and nucleic acid constructs encoding the SIRPlalpha-4lBBL fusion protein, host-cells expressing the SIRPlalpha-4lBBL fusion protein and methods of use thereof.
Bibliography:Application Number: IL20190267862