Cell therapy with polarized macrophages for tissue regeneration

The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype useful for tissue repair. The method described in the present invention comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated M2 macrophages obtained by t...

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Main Authors Jaime SANCHEZ MORENO, Xavier GINESTA BUCH, Ruben DOMINGUEZ SANCHEZ, Jorge Vicente MARTIN CORDERO, Pablo GARCIA DE LA RIVA MESTRE, Anna RODRIGUEZ GARCIA, Ana Maria SOLA MARTINEZ, Adrian CASTILLO GARCIA, Maria Georgina HOTTER CORRIPIO
Format Patent
LanguageEnglish
Hebrew
Published 01.11.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype useful for tissue repair. The method described in the present invention comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated M2 macrophages obtained by this method overexpress molecules important for tissue remodeling and amelioration of inflammation, such as NGAL and antiinflammatory cytokines (IL-10). Thus, M2 macrophages obtained by this method are useful as cell therapy for tissue regeneration. The invention also provides pharmaceutical compositions and kits comprising the M2 macrophages obtained by the described method.
Bibliography:Application Number: IL20190265488