Veto cells generated from memory t cells

A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transp...

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Bibliographic Details
Main Authors Rotem GIDRON BUDOVSKY, Sivan KAGAN, ESTHER BACHAR-LUSTIG, ASSAF LASK, YAIR REISNER, NOGA OR-GEVA
Format Patent
LanguageEnglish
Hebrew
Published 03.02.2019
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Summary:A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) providing a population of at least 70% memory T cells; (b) contacting the population of memory T cells with an antigen or antigens so as to allow enrichment of antigen reactive cells; and (c) culturing the cells resulting from step (b) in the presence of cytokines so as to allow proliferation of cells comprising the Tcm phenotype. Cells generated by the method, pharmaceutical compositions and methods of treatment are also disclosed.
Bibliography:Application Number: IL20180263924