(2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase i inhibitors

The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including...

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Main Authors SWALLOW Steven, PONTEN John Fritiof, JONES Graham Peter, CONNOLLY Stephen, PALMER Nicholas John, KARLSSON Staffan PO, VAN DE POEL Amanda Jane, LONN Hans Roland, AURELL Carl-Johan, WATSON David Wyn, DOYLE Kevin James, MACRITCHIE Jaqueline Anne
Format Patent
LanguageEnglish
Hebrew
Published 31.08.2017
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Summary:The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.
Bibliography:Application Number: IL20170252836