Triazolone compounds and uses thereof

The invention disclosed herein is directed to compounds of Formula Iand pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical com...

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Main Authors NICHOLAS SIMON STOCK, JILL MELISSA BACCEI, AUSTIN CHIH-YU CHEN, BRIAN ANDREW STEARNS, JASON DUARTE JACINTHO, YALDA MOSTOFI BRAVO, RYAN CHRISTOPHER CLARK
Format Patent
LanguageEnglish
Hebrew
Published 30.08.2018
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Summary:The invention disclosed herein is directed to compounds of Formula Iand pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to methods of treating prostate, breast, ovarian, liver, kidney, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administration of a therapeutically effective amount of a selective PPARα antagonist. The compounds and pharmaceutical compositions of the invention are also useful in the treatment of viral infections, such as HCV infections and HIV infections.
Bibliography:Application Number: IL20150239372