Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives

• Main Authors: EDDY JEAN EDGARD FREYNE, ALFONS HERMAN MARGARETHA RAEYMAEKERS
• Format: Patent
• Language: English
• Published: 13.02.1991
• Edition: 5
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives of formula the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein R is hydrogen, C1-6alkyl, phenyl; substituted phenyl; pyridinyl; or thienyl optionally substituted with halo or C1-6alkyl; R is hydrogen of C1-6alkyl; R is hydrogen, C1-6alkyl, hydroxyC1-6alkyl or phenyl; or R and R taken together may also form a C1-5alkanediyl radical; X is a radical of formula =O (a), =N-O-R (b),or =CH-R (c); R is hydrogen, tri(C1-6alkyl)silyl or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R ; R is COOH, COOC1-4alkyl, CONR R , COOCH2CONR R or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R . Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions.