Phenoxy-substituted beta-carboline derivatives, their production and their use as drugs

• Main Authors: STEPHENS DAVID NORMAN DR, HANSEN JOHN BONDO DR, SCHMIECHEN RALPH DR, PETERSEN ERLING DR, SEIDELMANN DIETER DR, ENGELSTOFT MOGENS DR, HUTH ANDREAS DR, SCHNEIDER HERBERT HANS DR
• Format: Patent
• Language: English
• Published: 16.11.1994
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Phenoxy-substituted beta-carbolines of the formula I (I) X is COOR3, CONHC1-3-alkyl or oxadiazolyl of the formula R2 is H, lower alkyl or cycloalkyl, R3 is lower alkyl, R4 is hydrogen, lower alkyl or lower alkoxyalkyl, R1 is hydrogen, halogen, lower alkyl, lower alkoxy, acyl, phenyl, C2-5 alkylenedioxy, trifluoromethyl, nitrilo, nitro, lower alkoxycarbonyl, azido, SO2R6, SO2NR7R8, or NR9R10, R6 is lower alkyl, R7 and R8 independently are lower alkyl or together with the nitrogen atom form a hetero ring, R9 and R10 independently are hydrogen, lower alkyl, acyl or together with the nitrogen atom form a hetero ring system, with the proviso that X is not COOEt, if (a) is 5-phenoxy and R4 is methyl or (b) is 6-(4-methoxyphenoxy) and R4 is methoxymethyl have valuable pharmacological properties.