Phenoxy-substituted beta-carboline derivatives, their production and their use as drugs

Phenoxy-substituted beta-carbolines of the formula I (I) X is COOR3, CONHC1-3-alkyl or oxadiazolyl of the formula R2 is H, lower alkyl or cycloalkyl, R3 is lower alkyl, R4 is hydrogen, lower alkyl or lower alkoxyalkyl, R1 is hydrogen, halogen, lower alkyl, lower alkoxy, acyl, phenyl, C2-5 alkylenedi...

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Main Authors STEPHENS DAVID NORMAN DR, HANSEN JOHN BONDO DR, SCHMIECHEN RALPH DR, PETERSEN ERLING DR, SEIDELMANN DIETER DR, ENGELSTOFT MOGENS DR, HUTH ANDREAS DR, SCHNEIDER HERBERT HANS DR
Format Patent
LanguageEnglish
Published 16.11.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Phenoxy-substituted beta-carbolines of the formula I (I) X is COOR3, CONHC1-3-alkyl or oxadiazolyl of the formula R2 is H, lower alkyl or cycloalkyl, R3 is lower alkyl, R4 is hydrogen, lower alkyl or lower alkoxyalkyl, R1 is hydrogen, halogen, lower alkyl, lower alkoxy, acyl, phenyl, C2-5 alkylenedioxy, trifluoromethyl, nitrilo, nitro, lower alkoxycarbonyl, azido, SO2R6, SO2NR7R8, or NR9R10, R6 is lower alkyl, R7 and R8 independently are lower alkyl or together with the nitrogen atom form a hetero ring, R9 and R10 independently are hydrogen, lower alkyl, acyl or together with the nitrogen atom form a hetero ring system, with the proviso that X is not COOEt, if (a) is 5-phenoxy and R4 is methyl or (b) is 6-(4-methoxyphenoxy) and R4 is methoxymethyl have valuable pharmacological properties.
Bibliography:Application Number: IE19860002996