TURUNAN BARU AMIDINOBENZENA TERSUBSTITUSI DAN KOMPOSISI-KOMPOSISI FARMASI DARI PADANYA

A substituted-amidinobenzene derivative of the following general formula (I) or a salt thereof, and a pharmaceutical composition comprising said derivative or a salt thereof and a pharmaceutically acceptable carrier. (the symbols in the above formula have the following meanings: R : a group which ca...

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Bibliographic Details
Main Authors SEIJIRO AKAMATSU, TOMIHISA KAWASAKI, SEIJI KAKU, ISAO YANAGISAWA, MASATO ICHIHARA, YUZO MATSUMOTO
Format Patent
LanguageIndonesian
Published 27.11.1997
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A substituted-amidinobenzene derivative of the following general formula (I) or a salt thereof, and a pharmaceutical composition comprising said derivative or a salt thereof and a pharmaceutically acceptable carrier. (the symbols in the above formula have the following meanings: R : a group which can be converted into an amidino group in vivo; R and R : the same or different and each represents a carboxyl group or a group which can be converted into a carboxyl group in vivo; X and X : the same or different and each represents a lower alkylene group; m: 0, 1 or 2, n: 0 or 1, provided that n = 1 when m = 0. They have GPIIb/IIIa receptor antagonizing activity and are useful as medicines for ameliorating ischemic cardiac disorders, adminicula in cardiosurgery operations or in vascular surgery operations, medicines for ameliorating cerebrovascular disorders, and medicines for ameliorating peripheral artery disorders. In addition, they are useful as a prodrug excellent in peroral absorbability and sustainment of the effect.
Bibliography:Application Number: ID19970001837