PHARMACEUTICAL COMPOSITION HAVING POTENTIATOR ACTIVITY FOR NERVE GROWTH FACTOR CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF

• Main Authors: NARITA,HIROKAZU, ONO,SATOSHI, MAEKAWA,MUTSUKO, HIRATA,KAZUNARI
• Format: Patent
• Language: English; Hungarian
• Published: 30.03.1998
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

A remedy for diseases caused by degeneration of central nervous system, comprising a 1,2-ethanediol derivative represented by the following general formula or its salt: wherein R represents a substituted or unsubstituted phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl or heterocyclic group; R represents a hydrogen atom, a C1-6alkyl group or a hydroxyl-protecting group; R represents a hydrogen atom or a C1-6alkyl group; nR 's may be the same as or different from one another and each represents a hydrogen atom or a C1-6alkyl group; nR<5'>s may be the same as or different from one another and each represents a hydrogen atom or a C1-6alkyl group; R represents a substituted or unsubstituted amino or nitrogen-containing heterocyclic group or an ammonio group; and n represents 0 or an integer of 1 to 6, provided that the following 1,2-ethanediol derivative represented by general formula or its salt: wherein nR 'S may be the same as or different from one another and each represents a fluorine, chlorine, bromine or iodine atom, C1-6alkyl, C1-6alkoxy or phenyl group; R represents a hydrogen atom or a hydroxyl-protecting group; R represents a C1-6alkyl-substituted amino group or a pyrrolyl, pyrrolidinyl, piperidyl, piperazinyl, imidazolyl, pyrazolyl, pyridyl, tetrahydropyridyl, pyrimidinyl, morpholinyl, thiomorpholinyl, quinolyl, quinolidinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, quinuclidinyl, thiazolyl, tetrazolyl, thiadiazolyl, pyrrolinyl, imidazolinyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl, purinyl, indazolyl, furyl, thienyl, benzothienyl, pyranyl, isobenzofuranyl, oxazolyl, benzofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, quinoxalyl, dihydroquinoxalinyl, 2,3-dihydrobenzothienyl, 2,3-dihydrobenzopyrrolyl, 2,3-dihydro-4H-1-thianaphthyl, 2,3-dihydrobenzofuranyl, benzoÄbÜdioxanyl, imidazoÄ2,3-aÜpyridyl, benzoÄbÜpiperazinyl, chromenyl, isothiazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, pyridazinyl, isoindolyl or isoquinolyl group; and n represents an integer of 1 to 5, is excluded.