NOVEL ANTIMICROBIAL AGENTS

• Main Authors: LANGE,BARRY CLIFFORD, OSEI-GYIMAH,PETER
• Format: Patent
• Language: English
• Published: 28.11.1995
• Edition: 5
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; TRAPPING

Isothiazolone derivs. of formulae (I) and (II) are new. R = H, halogen or 1-4C alkyl; R1 = H or halogen; or R and R1 together form a fused-on 5- to 7-membered carbocyclic ring which may be aromatic; R2 = H or 1-3C alkyl; R3 = H, or opt. substd. 1-18C alkyl, 2-18C alkenyl, 2-18C alkynyl, 4-8C cycloalkyl, 4-8C cycloalkenyl or aralkyl. R = H; R1 = H or Cl; R2 = CH3; R3 = H, CH3, pentyl or 1,4-benzoquinone. (I) and (II) are antimicrobial agents, active against a broad spectrum of bacterial fungi e.g. PS. aerujinosa, E. coli, S. aureus and Aspergillus niger. They may be used to protect e.g. wood , paint, adhesives, paper, textile, leather, plastics, cardboard, lubricants, cosmetics, food, coating, feed and industrial cooling water from microbial attack.