NOVEL BENZOYL AMINO ACID DERIVS., PHARMACEUTICAL COMPNS. CONTH. THEM AND PROCESS TO PREPARE THEM

• Main Authors: SUTKA,KLARA, GAL,EVA, TOLDY,LAJOS, SEBESTYEN,LASZLO, SIMAY,ANTAL, ZARA DENESNE,DR, GOLDSCHMIDTNE HORVATH,KATALIN, ANDRASI,FERENC, SZIRAKI,ISTVAN, FITTLER,ZSUZSANNA, HODULANE SZENTKUTI,ESZTER, VITKOCZINE KARDOS,VALERIA, RUSZNE PATFALUSI,MARTA, PAPPNE BEHR,AGNES, MATYUS,PETER, FARKAS,LAJOS, MATE GYOERGYNE,DR
• Format: Patent
• Language: English
• Published: 28.09.1995
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The peroxidation of lipids inhibiting N-benzoylamino acid derivatives of the general formula (I), wherein R and R , which are the same or different, stand for a hydroxyl group optionally bearing an acetyl group; or a C1-6alkoxy group optionally substituted by a phenyl group; R represents: hydroxyl group; C1-10alkoxy group; or a C1-4alkoxy group optionally substituted by a phenoxy group optionally bearing a nitrogen-containing substituent; or an -NR R group, where R and R , which are the same or different, mean: hydrogen; hydroxyl group; C1-12alkyl group; C1-4alkyl group optionally substituted by a hydroxyl group or an amino group; R and R together with the adjacent nitrogen form an optionally substituted 5- or 6-membered heterocyclic group optionally containing an additional nitrogen atom, this heterocyclic group optionally being substituted by an oxo group or an optionally phenyl-substituted C1-4alkyl group or C3-5alkenyl group; and when being piperazine, this heterocyclic group may be substituted also by a diaminopyrimidinyl or di(pyrrolidino)-pyrimidinyl group; and n means an integer from 2 to 15 with the proviso that: when R means hydroxyl group and n is 5, as well as one of R and R means a 4-hydroxyl group, then the other one of R and R is different from a 3-hydroxyl or 3-methoxy group; and when n is 2 or 3, then R and R cannot simultaneously stand for 2- and 3-methoxy group, as well as their tautomers, racemates and optically active individual (pure) isomers or mixtures thereof and the salts of these compounds and pharmaceutical compositions containing these compounds.