NOVEL 1-ARYLSULPHONYL-, -ARYLCARBONYL- AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDRO-PYRIDAZINES

PCT No. PCT/US93/06394 Sec. 371 Date Mar. 6, 1995 Sec. 102(e) Date Mar. 6, 1995 PCT Filed Jul. 1, 1993 PCT Pub. No. WO94/01412 PCT Pub. Date Jan. 20, 1994Disclosed are progestin agonists having the following formula: wherein: A is W is absent or -CH=CH-; R1 are independently selected from the group...

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Bibliographic Details
Main Author COMBS,DONALD W
Format Patent
LanguageEnglish
Published 28.06.1995
Edition5
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/US93/06394 Sec. 371 Date Mar. 6, 1995 Sec. 102(e) Date Mar. 6, 1995 PCT Filed Jul. 1, 1993 PCT Pub. No. WO94/01412 PCT Pub. Date Jan. 20, 1994Disclosed are progestin agonists having the following formula: wherein: A is W is absent or -CH=CH-; R1 are independently selected from the group consisting of halogen, -CF3, and NO2, or both R1 may be joined to form a bi-radical which is -CH=CHCH=CH-; R3 are independently selected from the group consisting of hydrogen, C1-6 branched or linear alkyl, halogen and -CF3, with the proviso that R3 at the 3-position must be H where R3 at the 4-position is H, or both R3 may be joined to form a bi-radical selected from the group consisting of -CH=CHCH=CH-, -C(NC1-4alkyl2)=CHCH=CH- and -(CH2)4-; R5 is selected from the group consisting of H and Me; with the proviso that only one of R1 and R3 forms the fused bi-radical; and the stereoisomers.
Bibliography:Application Number: HU19940003841