PROCESS FOR PREPG. NEW BACIS ETHERS AND PHARMACEUTICAL COMPN.S CONTAINING THEM

• Main Authors: FEKETE,MARTON, SCHMIDT,EVA, MEZEI,TIBOR, BLASKO,GABOR, SZEMEREDI,KATALIN, SZIRTNE KISZELLY,ENIKOE, BUDAI,ZOLTAN, REITER,JOZSEFNE, GYERTYAN,ISTVAN, EGYED,ANDRAS, GACSALYI,ISTVAN, SIMIG,GYULA, BAJNOGEL,JUDIT
• Format: Patent
• Language: English
• Published: 28.03.1995
• Edition: 5
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A subject-matter of the invention are 1-(Phenyl)-3-[ omega -(amino)-alkoxyimino]-alk-1-ene derivatives of general formula wherein R1 and R2 independently each stands for hydrogen, halogen or a C1-4 alkoxy group or together represent a 3,4-methylenedioxy group, R stands for C1-8 alkyl, R3 represents hydrogen, C1-4 alkyl or hydroxy, R4 and R5 independently each represents hydrogen, a C1-12 alkyl group, optionally substituted by hydroxy, or a C2-12 alkenyl or C3-6 cycloalkyl group, or R4 and R5 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclic ring, optionally comprising an oxygen, sulfur or a further nitrogen atom, which latter optionally may carry a phenyl, benzyl or C1-4 alkyl substituent and A represents a valency bond or a -CH2-group, as well as stereo and optically active isomers and their mixtures, acid-addition salts and quaternary ammonium derivatives thereof. Furthermore the invention is concerned with a process for preparing these compounds as well as medicaments containing them and the use of them for preparing medicaments, particularly having ulcus and gastric-acid-secretion inhibiting and anxiolytic effects.