PROCESS FOR PRODUCING COMPOSITION SUITABLE FOR TREATING INFECTIONS CAUSED BY ORGANISMS SENSITIVE TO BETA-LACTAM ANTIBIOTICS

The invention is directed to compositions and methods for treating an infection caused by an organism susceptible to a beta -lactam antibiotic comprising two or more active agents. In one embodiment, the composition comprises: (1) a beta -lactam antibiotic and (2) a cationic oligopeptide. In another...

Full description

Saved in:
Bibliographic Details
Main Authors COSAND,WESLEY L.,US, DARVEAU,RICHARD P.,US, BLAKE,JAMES J.,US
Format Patent
LanguageEnglish
Published 28.09.1993
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention is directed to compositions and methods for treating an infection caused by an organism susceptible to a beta -lactam antibiotic comprising two or more active agents. In one embodiment, the composition comprises: (1) a beta -lactam antibiotic and (2) a cationic oligopeptide. In another embodiment, the invention is also directed to a composition comprising: (1) a beta -lactam antibiotic which inhibits the growth of Enterobacteriaceae bacteria and (2) at least one membrane active substance. Further, the invention is also directed to improved methods for screening potential bactericidal compositions in vitro wherein components of an active complement cascade are included.
Bibliography:Application Number: HU19920002720