PROCESS FOR PRODUCING 17-ALPHA-HYDROXY-20-OXOPREGNANE STEROID DERIVATIVES

The invention relates to a novel process for the preparation of 17 alpha -hydroxy-20-oxopregnane derivatives of the general formula (I), (I) wherein R1 means a hydroxy or an oxo group; and the dotted lines optionally represent one or more additional valence bond(s), with the proviso that the dotted...

Full description

Saved in:
Bibliographic Details
Main Authors PALLAGI,ISTVAN,HU, MAKK,NANDOR,HU, SZEDERKENYI,FERENC,HU, MORAVCSIK,IMRE,HU, ILKOEY,EVA,HU, AMBRUS,GABOR,HU, KOENCZOEL,KALMAN,HU, JEKKEL ANTALNE,DR.,HU, HORVATH,GYULA,HU, TORO,ANDRAS,HU
Format Patent
LanguageEnglish
Published 28.01.1992
Edition5
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
Online AccessGet full text

Cover

More Information
Summary:The invention relates to a novel process for the preparation of 17 alpha -hydroxy-20-oxopregnane derivatives of the general formula (I), (I) wherein R1 means a hydroxy or an oxo group; and the dotted lines optionally represent one or more additional valence bond(s), with the proviso that the dotted line in the 4-position and the dotted line in the 5-position cannot each simultaneously be an additional valence bond from steroids having 23,24-dinor-17(20)-dehydrocholan-22-oic -22-oic acid structure. According to the process of the invention a steroid derivative having 23,24-dinorcholan-22-oic acid structure, containing a double bond in 17(20)-position, is transformed to 17 alpha , 20-epoxy-23,24-dinorcholanoic acid, the latter is converted to a reactive acid derivative, which is then reacted with a salt-containing azide ion to yield a 17 alpha , 20-epoxy-23,24-dinorcholanoic acyl azide derivative and the azide obtained is reacted with a mineral or organic acid in an aqueous medium.
Bibliography:Application Number: HU19900003896