PROCESS FOR PRODUCING ISOMER-FREE4-HYDROXY-7-CHLOROQUINOLINE
4-hydroxy-7-chloro-quinoline of general formula (I) is prepd. free of isomers at 60-130 deg. C temp. and 0.1-0.6 MPa pressure from di: or tri:-ethyl-malonate, tri:ethyl-or tri:methyl-o-formate and 3-chloro-aniline, in the presence of metallic magnesium or of magnesium-oxide hydroxide or carbonate an...
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Main Authors | , , , , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
30.12.1991
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Edition | 5 |
Subjects | |
Online Access | Get full text |
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Summary: | 4-hydroxy-7-chloro-quinoline of general formula (I) is prepd. free of isomers at 60-130 deg. C temp. and 0.1-0.6 MPa pressure from di: or tri:-ethyl-malonate, tri:ethyl-or tri:methyl-o-formate and 3-chloro-aniline, in the presence of metallic magnesium or of magnesium-oxide hydroxide or carbonate and/or unsubstd. chloro-aniline-, or 1-4C alkyl gp. (identical or dissimilar) substd. ammonium-chloride as catalyst. 2-carbomethoxy-3-(3-chloro-anilino)- methyl-acrylate (VI) is obtd. and is converted to cyclic quinoline-3-carboxylic-ester (II) at 180-280 deg. C in an inert solvent R:methyl gp. in (II). The prod. is hydrolysed and is decarboxylated thermally to cpd.(I). (1pp Dwg.No.0/0) |
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Bibliography: | Application Number: HU19900003314 |