PROCESS FOR PRODUCING ISOMER-FREE4-HYDROXY-7-CHLOROQUINOLINE

4-hydroxy-7-chloro-quinoline of general formula (I) is prepd. free of isomers at 60-130 deg. C temp. and 0.1-0.6 MPa pressure from di: or tri:-ethyl-malonate, tri:ethyl-or tri:methyl-o-formate and 3-chloro-aniline, in the presence of metallic magnesium or of magnesium-oxide hydroxide or carbonate an...

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Bibliographic Details
Main Authors BOLDOG,JANOS,HU, REPASINE VERES,AGOTA,HU, GULYAS,IMRE,HU, MESTER,TAMAS,HU, GAJDACS,PAL,HU, KOERTVELYESSY,GYULA,HU, VISY,ANDRAS,HU, PUSKAS,ATTILA,HU, REPASI,JANOS,HU, SZATMARI,ANTAL,HU, KOERTVELYESSI,GYULANE,HU, KALMAN,GYOERGY,HU, VARGA,GABOR,HU
Format Patent
LanguageEnglish
Published 30.12.1991
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:4-hydroxy-7-chloro-quinoline of general formula (I) is prepd. free of isomers at 60-130 deg. C temp. and 0.1-0.6 MPa pressure from di: or tri:-ethyl-malonate, tri:ethyl-or tri:methyl-o-formate and 3-chloro-aniline, in the presence of metallic magnesium or of magnesium-oxide hydroxide or carbonate and/or unsubstd. chloro-aniline-, or 1-4C alkyl gp. (identical or dissimilar) substd. ammonium-chloride as catalyst. 2-carbomethoxy-3-(3-chloro-anilino)- methyl-acrylate (VI) is obtd. and is converted to cyclic quinoline-3-carboxylic-ester (II) at 180-280 deg. C in an inert solvent R:methyl gp. in (II). The prod. is hydrolysed and is decarboxylated thermally to cpd.(I). (1pp Dwg.No.0/0)
Bibliography:Application Number: HU19900003314