NEW PROCESS FOR PRODUCING 2,2-DIMETHYL-5-(2,5-DIMETHYLPHENOXY)-PENTANOIC ACID

• Main Authors: SIMAY,ANTAL,HU, TOLDY,LAJOS,HU, KRASZNAI,GYOERGY,HU, VERECZKEYNE DONATH,GYOERGYI,HU, ZUBOVICS,ZOLTAN,HU, FEHER,GABOR,HU, MORAVCSIK,IMRE,HU, SZEDERKENYI,FERENC,HU, KOVACS,GABOR,HU, NAGY,KALMAN,HU, KOVACSNE BOZO,EVA,HU
• Format: Patent
• Language: English
• Published: 28.11.1991
• Edition: 5
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) which comprises reacting an ester of the general Formula (X) (X) wherein X represents halogen and Z stands for a straight or branched chain C1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group-with an alkali salt of 2,5-dimethylphenol of Formula (II) (II) or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. (XI) Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof.