PROCESS FOR PRODUCING BIPHENYLMETHANE DERIVATIVES INCLUDING CONDENSED CARBO OR HETEROCYCLIC IMIDAZOLE UNIT, AS WELL AS PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS

• Main Authors: HAMANO,SACHIYUKI,JP, MIYAKE,KAZUTOSHI,JP, MORI,NOBUYUKI,JP, YONEDA,NAOKI,JP, HIROSHIMA,OSAMU,JP, MATSUKURA,MASAYUKI,JP, MUSHA,TAKASHI,JP, MINAMI,NORIO,JP, MATSUOKA,TOSHIYUKI,JP, ISHIHARA,HIROKI,JP
• Format: Patent
• Language: English
• Published: 28.05.1991
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are biphenylmethane derivatives having the formula: wherein R and R , which may be the same or different, are each a hydrogen atom, a halogen atom, a lower C1-6 alkyl group a lower C1-6 alkoxy group, a carbamoyl group or a cyano group; R stands for hydrogen or a lower C1-6 alkyl group; R is 1H-tetrazol-5-yl, a carboxyl (-COOH) group or a carboxylic ester thereof; R stands for hydrogen, a halogen atom, a hydroxy group or a lower C1-6 alkoxy group, or a pharmacologically acceptable salt thereof, wherein compounds having the following formula and their pharmacologically acceptable salts are excluded: wherein R is 1H-tetrazol-5-yl, a carboxyl (-COOH) group or a carboxylic ester thereof and n is an integer of 1 to 2; or a pharmacologically acceptable salt thereof. Further, a process for their preparation, pharmaceutical compositions containing same and their use for the preparation of such compositions for preventing and treating hypertension and/or cardiac failure are disclosed.