NEW PROCESS FOR PRODUCING (2,4,6,7-3H)-ESTRA-1,3,5(10)-TRIEN-3,17BETA-OL

For novel prepn. of (2,4,6,7-(3)4) -oestra-1,3,5-(10)-triene-3,17 beta-diol, 3,17beta-di:acetoxy-2,4- di:bromo-1,3,5-(10)-6-oestra tetraene reacts with substrate free tritium gas in an aprotic organic solveht, in the presence of a hydrogenating catalyst and an acid scavenging base. - Protective acet...

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Main Authors VOLFORD,JANOS,HU, BURSICS,LASZLO,HU, KROMER,ISTVAN,HU, VINCZE,IREN,HU, SZENDI,ZSUZSANNA,HU
Format Patent
LanguageEnglish
Published 28.07.1990
Edition5
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:For novel prepn. of (2,4,6,7-(3)4) -oestra-1,3,5-(10)-triene-3,17 beta-diol, 3,17beta-di:acetoxy-2,4- di:bromo-1,3,5-(10)-6-oestra tetraene reacts with substrate free tritium gas in an aprotic organic solveht, in the presence of a hydrogenating catalyst and an acid scavenging base. - Protective acetoxy gps. are removed subsequently by alkaline hydrolysis. - The prod. is suitable for the data of oestrogen receptors.
Bibliography:Application Number: HU19880005775