PROCESS FOR PRODUCING AMPHOTERICIN B CRYSTALS IN FERMENTATION MEDIUM

A method for the prodn. of amphotericin B (AB) crystals directly in a fermentation medium comprises (a) cultivating a strain of Streptomyces nodosus in a fermentation medium which is free of organic solvent for AB until antifungal activity is imparted to the medium, (b) heating the medium at 70-130...

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Bibliographic Details
Main Authors SZARKA,LASZLO J.,US, KO,RAPHAEL Y.,US
Format Patent
LanguageEnglish
Published 30.10.1989
Edition4
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Summary:A method for the prodn. of amphotericin B (AB) crystals directly in a fermentation medium comprises (a) cultivating a strain of Streptomyces nodosus in a fermentation medium which is free of organic solvent for AB until antifungal activity is imparted to the medium, (b) heating the medium at 70-130 deg.C for at least 10 mins. to form crystals of AB and (c) recovering the crystals of AB from the medium. Crystals of AB may be added to the fermentation medium to induce crystal formation. Lysozyme, protease, glucanase, papain, trypsin or pepsin may be added after the heating step to complete the crystal formation.
Bibliography:Application Number: HU19880001079