PROCESS FOR PRODUCING LAYERED MEDICINE FORM OF PROLONGED EFFECT CONTAINING AGENT RESORPTING THROUGH EPIDERMIS

The invention relates to a transdermal laminated pharmaceutical composition (plaster) having prolonged effect, wherein one or more storing layer(s) comprising the active ingredient, an ethylene/vinyl acetate copolymer regulating layer and an adhesive layer are applied onto the carrier. The pharmaceu...

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Bibliographic Details
Main Authors FEKETE,PAL,HU, MAHR,LAJOS,HU, BARTHA,IREN,HU, PALLOS,LASZLO,HU, KOVACS,GABOR,HU
Format Patent
LanguageEnglish
Published 28.04.1988
Edition4
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to a transdermal laminated pharmaceutical composition (plaster) having prolonged effect, wherein one or more storing layer(s) comprising the active ingredient, an ethylene/vinyl acetate copolymer regulating layer and an adhesive layer are applied onto the carrier. The pharmaceutical composition is prepared by coupling a carrier comprising the active ingredient with a regulating layer consisting of an ethylene/vinyl acetate copolymer foil having a vinal acetate content of 2-40 molar %. The foil is previously irradiated in a thickness of 100-300 mu m with a high-energy irradiation in a dose of 1-15 Mrad-preferably with electrone radiation-and thereafter stretched at 80 DEG -90 DEG C. to a thickness of 2-200 mu m. The system comprising the carrier and the regulating layer is subsequently coupled with an adhesive layer.
Bibliography:Application Number: HU19860004117