PROCESS FOR PREPARING NOVEL DECAHYDROQUINOLINE DERIVATIVES AND THEIR SALTS, AS WELL AS PHARMACEUTICS COMPRISING THE DERIVATIVES

Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula I wherein R1 and R2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocy...

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Bibliographic Details
Main Authors CLEMENCE,FRANC,OIS,FR, FORTIN,MICHEL,FR, LE MARTRET,ODILE,FR, DELEVALLEE,FRANC,OISE,FR
Format Patent
LanguageEnglish
Published 30.11.1987
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula I wherein R1 and R2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of -(CH2)n- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.
Bibliography:Application Number: HU19870000099