PROCESS FOR PREPARING NOVEL CARBACYCLINES AND PHARMACEUTICS COMPRISING SUCH COMPOUNDS

Carbacycline derivatives of general formula (I), in which Y1 is the residue of Formula (II), R9 is the residue -(CH2)m-R6 or the residue -(CH2)m-o-[Z1-(CH2)m-p]x-[Z2-(CH2)m-q]y-R6, m = 2-20; o, p and q <= 19; x, y = 0, 1 or 2; Z1 is a cis-CH=CH-group, a trans-CH=CH-group or a -C=C-group, whereby...

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Bibliographic Details
Main Authors KLAR,ULRICH,DE, STUERZEBECHER,CLAUS-STEFFEN,DE, VORBUEGGEN,HELMUT,DE, NIEUWEBOER,BOB,DE
Format Patent
LanguageEnglish
Published 30.11.1987
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Carbacycline derivatives of general formula (I), in which Y1 is the residue of Formula (II), R9 is the residue -(CH2)m-R6 or the residue -(CH2)m-o-[Z1-(CH2)m-p]x-[Z2-(CH2)m-q]y-R6, m = 2-20; o, p and q <= 19; x, y = 0, 1 or 2; Z1 is a cis-CH=CH-group, a trans-CH=CH-group or a -C=C-group, whereby each of these groups must be separated at least by one methyl group from the C-9 carbon atom of the carbacycline bi-cycle; Z2 is oxygen, sulphur, an NH or an N-methyl group, R6 is amino, methylamino, hydroxy, carboxy or mercapto; and process for their manufacture and their use as medicaments.
Bibliography:Application Number: HU19860005587