PROCESS FOR PRODUCTION OF N-/2-AMIN-ACYL-AMIDO-2-DISOXIHEXORIL/-AMIDS, CARBAMATES AND CARBAMIDES AND ALSO MEDICAL PREPARATIVES CONTAINING THEREOF

• Main Authors: BRUNNER,HELMUT,DE, SCHALLER,KLAUS,DE, STADLER,PETER,DE, PAESSENS,ARNOLD,DE, KROLL,HEIN-PETER,DE, ZEILER,HANS-JOACHIM,DE, STREISSLE,GERT,DE, LOCKHOFF,OSWALD,DE, STUENKEL,KLAUS G.,DE, METZGER,KARL G.,DE, KLIMETZEK,VOLKER,DE, HAYAUCHI,YUTAKA,DE
• Format: Patent
• Language: English
• Published: 30.03.1987
• Edition: 4
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

Compounds of the formula in which R1 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, X represents -CH2-, -O-or -NH-, R2 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, R3, R4 and R5, independently of one another, denotes hydrogen or acyl-CO-R6, R6 being an alkyl radical having up to 10 carbon atoms, R7 denotes hydrogen, C1-C7-alkyl-, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-(methylthio)-ethyl, 3-aminopropyl, 3-ureidopropyl, 3-quanidyl-propyl, 4-aminobutyl, carboxymethyl, carbamylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, and R8 represents hydrogen or methyl, and R9 represents hydrogen, acetyl, benzoyl, trichloroacetyl, trifluoroacetyl, methoxycarbonyl, t-butyloxycarbonyl or benzyloxycarbonyl and R7 and R8 together can denote -CH2-CH2-CH2, and pharmaceutically acceptable salts thereof stimulate the immune system and can be used in conjuction with antibiotics and vaccines. New intermediates are also shown.