PROCESS FOR PREPARING AMINOGLUCOSIDE ANTIBIOTICS OF HIGH ACTIVITY AND PURITY

Amino-glycoside antibiotica like the new Gentoxymycin A and Gentoxymycin B, the known Gentamycin B and Gentamycin Bl as well as Sisomycin are prepd. in high purity from the raw antibiotica mixt, by sepg. the mixt. on a strongly basic fine grain ionexchange resin in the hydroxyl form into relatively...

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Main Authors KOCZKA,ISTVAN,HU, JARAI,MIKLOS,HU, ZLATOS,GABRIELLA,HU, PIUKOVICH,SANDOR,HU, BERDY,JANOS,HU, HORVATH,GYULA,HU, KADARNEE PAUNCZ,JUDIT,HU
Format Patent
LanguageEnglish
Published 29.09.1986
Edition4
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:Amino-glycoside antibiotica like the new Gentoxymycin A and Gentoxymycin B, the known Gentamycin B and Gentamycin Bl as well as Sisomycin are prepd. in high purity from the raw antibiotica mixt, by sepg. the mixt. on a strongly basic fine grain ionexchange resin in the hydroxyl form into relatively polar and apolar fractions using ion free water as eluent. The pure antibioticum components are sepd. from these fractions by cation exchange chromatography.
Bibliography:Application Number: HU19830004436