PROCESS FOR PREPARING SUBSTITUTED 7-OXO-MITOSANES

• Main Authors: DOYLE, TERRENCE W.,US, VYAS, DOLATRAI M.,US, PARTYKA, RICHARD A.,US
• Format: Patent
• Language: English
• Published: 28.07.1986
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Mitomycin A derivatives II and III which are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group, are prepared by reacting demethyl mitomycin A or a derivative thereof with an appropriate triazene Ar - N = N - NH - alk2 - S - S - alk1 - R or A...