PROCESS FOR PREPARING SUBSTITUTED 7-OXO-MITOSANES

Mitomycin A derivatives II and III which are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group, are prepared by reacting demethyl mitomycin A or a derivative thereof with an appropriate triazene Ar - N = N - NH - alk2 - S - S - alk1 - R or A...

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Bibliographic Details
Main Authors DOYLE, TERRENCE W.,US, VYAS, DOLATRAI M.,US, PARTYKA, RICHARD A.,US
Format Patent
LanguageEnglish
Published 28.07.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Mitomycin A derivatives II and III which are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group, are prepared by reacting demethyl mitomycin A or a derivative thereof with an appropriate triazene Ar - N = N - NH - alk2 - S - S - alk1 - R or Ar - N = N - NH - alk2 - S - S - R Mitomycin A is an antibiotic of established utility, and the 7-0-substituted mitosane analogs thereof have similar utility. The mitomycin A derivatives have the formula:- (Ar, alk1, alk2, R , R and R are various defined groups). The above process may also be used for the production of mitomycin A and derivatives thereof not containing the disulphide group.
Bibliography:Application Number: HU19850003335