PROCESS FOR THE PRODUCTION OF NEW 1,2,4-TRIAZOLA-DERIVATIVES

• Main Authors: HECKENDORN,ROLAND,CH, JAEGGI,KNUT,CH
• Format: Patent
• Language: English
• Published: 28.12.1985
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

1,2,4-Triazacycloalkadiene derivatives of the formula in which the radicals R1 and R2 independently of one another denote aryl or optionally N-oxidised heteroaryl groups which are unsubstituted or substituted by aliphatic hydrocarbon radicals, free, etherified or esterified hydroxyl, optionally S-oxidised etherified mercapto, free or aliphatically substituted amino, nitro and/or trifluoromethyl and R3 represents an unsubstituted aliphatic, hydrocarbon radical, having at least 2 C atoms or substituted by a cyano group, an optionally esterified or amidated carboxyl group, one or two optionally esterified or etherified hydroxyl group(s), one or two etherified mercapto group(s), an oxidised etherified mercapto group or an oxo group and optionally interrupted by thia or oxa or an unsubstituted cycloaliphatic hydrocarbon radical, and their salts have analgesic properties and can be used as pharmaceutical active substances for the treatment of painful inflammatory diseases. They are prepared, for example, by eliminating HY from a compound of the formula in which one of the radicals Y1 and Y2 denotes an eliminable radical Y and the other denotes a hydrogen atom and Y3 and Y4 together represent an additional bond, or in which Y4 denotes an eliminable radical Y and Y3 denotes hydrogen and Y1 and Y2 represent an additional bond, or from a salt thereof, with the introduction of an additional bond.