PROCESS FOR PRODUCTION OF IKERION-TYPE COMPOUNDS

The invention relates to new compounds of the general Formula I (I) and isomers thereof wherein R1 is C1-10 alkyl, C3-6 cycloalkyl or phenyl, naphthyl or phenyl-(C1-4 alkyl), wherein the aryl ring of the three latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydr...

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Main Authors GRASSER,KATALIN,HU, PETOECZ,LUJZA,HU, PALLOS,LASZLO,HU, HAJOS,GYOERGY,HU, SZIRTNE KISZELLY,ENIKOE,HU, MESSMER,ANDRAS,HU, BENKO,PAL,HU, BATORI,SANDOR,HU
Format Patent
LanguageEnglish
Published 28.06.1985
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new compounds of the general Formula I (I) and isomers thereof wherein R1 is C1-10 alkyl, C3-6 cycloalkyl or phenyl, naphthyl or phenyl-(C1-4 alkyl), wherein the aryl ring of the three latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C1-4 alkyl and/or C1-4 alkoxy substituent(s); R2 stands for hydrogen, halogen, hydroxy, oxo, C1-4 alkyl, C1-4 alkoxy, phenyl or naphthyl, wherein the two latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C1-4 alkyl and/or C1-4 alkoxy substituent(s); R3 represents hydrogen, hydroxy or C1-4 alkoxy; Z is buta-1,3-dienyl or a group of the general Formula (a) (a) or (b) (b) and X is hydrogen or halogen. The compounds of the general Formula I possess useful pharmacological properties, particularly antidepressant and antiarrhythmial effect.
Bibliography:Application Number: HU19830003243