PROCESS FOR PREPARATION OF 2-FLUOR-PIRIMIDINE-DERIVATIVES

Prodn. of 2-fluoropyrimidines of formula (I) comprises reacting a 2-aminopyrimidine of formula (II) with a diazotising agent in 30-70% aq. HF at -60 to +40 degrees C, opt. in the presence of a diluent and/or salts.R -R = H; opt. substd. 1-6C alkyl, 1-6C alkoxy, aryl or heterocyclyl; or halo, 2-7C al...

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Bibliographic Details
Main Authors STEFFAN,GUIDO, WOLTERS,ERICH, KLAUSENER,ALEXANDER
Format Patent
LanguageEnglish
Published 28.02.1997
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Prodn. of 2-fluoropyrimidines of formula (I) comprises reacting a 2-aminopyrimidine of formula (II) with a diazotising agent in 30-70% aq. HF at -60 to +40 degrees C, opt. in the presence of a diluent and/or salts.R -R = H; opt. substd. 1-6C alkyl, 1-6C alkoxy, aryl or heterocyclyl; or halo, 2-7C alkoxycarbonyl, 2-7C alkanoyloxy, CN, di(1-6C alkyl)amino or SOnR , where n = 0-2 and R = opt. substd. 1-6C alkyl, 1-6C alkoxy, aryl, aryloxy or arylthio.
Bibliography:Application Number: HUP9601261