ADDUCTS OF INORGANIC SALTS BASEA ON VILDAELITPIN APPLICABLE FOR PREPARATION OF PHARMACEUTICAL COMPOSITIONS

• Main Authors: KOEHEGYI IMRE DR, DANCSO ANDRAS DR, PONGO LASZLO DR, VOLK BALAZS DR, NAGY KALMAN DR, BRODA JUDIT, DEBRECZENI JOZSEF DR, RUZSICS GYOERGY, BARKOCZY JOZSEF, KESZTHELYI ADRIENN, NEMETH GABOR DR, MRAVIK ANDRAS DR
• Format: Patent
• Language: English
• Published: 30.05.2011

The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.