PROCESS FOR PRODUCING PHARMACEUTICAL INTERMEDIERS

The invention relates to a process for the preparation of compounds of general formula (III), wherein R represents fluorine or chlorine atom and X represents chlorine or bromine atom, by halogenation of cyclopropyl benzyl ketone of general formula (II), wherein R represents fluorine or chlorine atom...

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Main Authors BARKOCZY JOZSEF DR, VOLK BALAZS DR, MEZEI TIBOR DR, MOLNAR ENIKOE, SZULAGYI JANOS, PORCS-MAKKAY MARTA DR, LUKACS GYULA DR, VAJJON MARIA
Format Patent
LanguageEnglish
Published 28.04.2010
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Summary:The invention relates to a process for the preparation of compounds of general formula (III), wherein R represents fluorine or chlorine atom and X represents chlorine or bromine atom, by halogenation of cyclopropyl benzyl ketone of general formula (II), wherein R represents fluorine or chlorine atom and the halogenation is carried out in the mixture of aqueous hydrogen halide and aqueous hydrogen peroxide in the presence of a water miscible solvent or in the presence of a phase transfer catalyst; or the halogenation is carried out in the mixture of sulfuric acid and an alkali metal salt of aqueous hydrogen halide. The process can be applied preferably on industrial scale.
Bibliography:Application Number: HUP0700757