NEW BENZOFURAN DERIVATIVES AS SELECTIVE INHIBITORS OF 5-HT6 AND PROCESS FOR THEIR PREPARATION

• Main Authors: PRAUDA IBOLYA, BARKOCZY JOZSEF DR, SZIRAY NORA, HEGEDUES ENDRE DR, HARSING LASZLO GABOR DR, RIVO ENDRE DR, REITER JOZSEF DR, GACSALYI ISTVAN, LEVAY GYOERGY DR, PALLAGI KATALIN, KOMPAGNE HAJNALKA, EGYED ANDRAS DR
• Format: Patent
• Language: English
• Published: 28.03.2011

The present invention relates to new selective 5HT6 receptor binding benzofuran derivatives of general formula (I) wherein, Z represents a hydrogen atom, C1-4 acyl group, C1-6 alkyl sulfonyl group, phenyl sulfonyl group substituted with one or more halogen atom; or naphthyl sulfonyl group optionally substituted with a halogen atom, tetrahydro naphthyl sulfonyl group, (lS)(+)-10-camphor-sulfonyl group, (lR)(-)-10-camphor-sulfonyl group or benzofuranyl sulfonyl group, substituted with a halogen atom and C1 -4 alkyl group, Y represents C2-6 alkylene group, R1 and R2 represent, independently, a hydrogen atom, C1-4 alkyl group, benzyl group, or together with one or more halogen atoms, trifluoromethyl group, or C1-4 alkoxy group substituted 4-phenyl-piperazine-l-yl group; and/or their pharmaceutically suitable acid addition salts, to the process for producing said compounds, to pharmaceutical compositions containing said compounds and to their use in treatment and/or prevention of disorders of the central nervous system and cardiovascular system.