NOVEL PROTEIN MARKER COMBINATORIAL LIBRARIES, PROCESS FOR THEIR PREPARATION AND THEIR USE

• Main Authors: KRAJCSI PETER DR, NAGY TAMAS DR, KALMAN FERENC DR, BUCSAI AGOTA, DARVAS FERENC DR, SZALAY DANIEL, DORMAN GYOERGY DR, BERES MARIANN DR, UERGE LASZLO DR
• Format: Patent
• Language: English; Hungarian
• Published: 28.04.2004
• Edition: 7

The invention consists substantially of combinatorial, protein-marker molecule libraries, having groups that may be chemically and photochemically activated, with or without reporter groups, connected in different diversity points or spatial arrangements via side chains around a common molecular core. The invention consists furthermore of combinatorial libraries of marker units having chemically or photochemically reactive marker groups, reporter groups, and various other types of side chains attached variably to a common molecular, preferably lysine-based, structural core. The invention consists furthermore of a method for combinatorial chemical tethering, where a side chain having a terminal functional group, preferably an amino group, and to which a marker group is optionally attached, is introduced in optimal position ensuring structural diversity and protein binding effectiveness. The invention contributes to simplifying complexity of proteome in different tissues and to the identification of protein markers for diagnosis by alternating different labeling pattern in healthy and diseased tissues.