CYCLIC AMINE DERIVATIVES AND THEIR USE AS DRUGS

A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1 alpha and/or MCP-1 on targe...

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Main Authors MORITA TAKUYA MORITA TAKUYA, TEIG STEVEN L. TEIG STEVEN L, HADA TAKAHIKO HADA TAKAHIKO, SHIOTA TATSUKI SHIOTA TATSUKI, ENDO NORIAKI ENDO NORIAKI, TAKENOUCHI OSAMI TAKENOUCHI OSAMI, KATAOKA KEN-ICHIRO KATAOKA KEN-ICHIRO, SOGAWA RYO SOGAWA RYO, MUROGA YUMIKO MUROGA YUMIKO, FURUYA MONORU FURUYA MONORU, TARBY CHRISTINE M. TARBY CHRISTINE M, IMAI MINORU IMAI MINORU, TSUTSUMI TAKAHARU TSUTSUMI TAKAHARU, SUDOH MASAKI SUDOH MASAKI, MOREE WILNA MOREE WILNA
Format Patent
LanguageEnglish
Published 28.03.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1 alpha and/or MCP-1 on target cells, they may be useful as a therapeutic drug and/or preventative drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
Bibliography:Application Number: HUP0004200