DIBENZOCYCLOHEPTENE DERIVATIVES AS VITRONECTIN RECEPTOR ANTAGONISTS, PROCESS FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis wherein: A is CH2 or O; R is H, halo or C1-6alkyl; R is H, C1-6alkyl or CH2NR''R''; X is O or CH2; Y is (a), (b), (c), (d), (e), (f) or (g); G is NR&#...

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Main Authors SAMANEN JAMES MARTIN SAMANEN JAMES MARTIN, MILLER WILLIAM H. MILLER WILLIAM H, HEERDING DIRK HEERDING DIRK, BONDINELL WILLIAM E. BONDINELL WILLIAM E
Format Patent
LanguageEnglish
Published 28.03.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis wherein: A is CH2 or O; R is H, halo or C1-6alkyl; R is H, C1-6alkyl or CH2NR''R''; X is O or CH2; Y is (a), (b), (c), (d), (e), (f) or (g); G is NR'', S or O; R' is H, C1-6alkyl, OC1-6alkyl, SC1-6alkyl, NR''R'' or halo; each R'' independently is H or C1-6alkyl; and s is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.
Bibliography:Application Number: HUP0003641