PROCESS FOR PREPARING 3(S)[(5-CHLORO-1H-INDOLE-2-CARBONYL)-AMINO]-2(R)-HYDROXY-4-PHENYL-BUTYRIC ACID AND INTERMEDIATES

The present invention provides novel processes for preparing 3(S)- (5-chloro-1H-indole-2-carbonyl)-amino­-2(R)-hydroxy-4-phenyl-butyric acid. Also provided are novel intermediates used in those processes. Further, the 3(S)- (5-chloro-1H-indole-2-carbonyl)-amino­-2(R)-hydroxy-4-phenyl-butyric acid pr...

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Main Authors HOOVER DENNIS JAY HOOVER DENNIS JAY, FOX DARREL EUGENE FOX DARREL EUGENE, JORGENSEN JEFFREY BRIAN JORGENSEN JEFFREY BRIAN, DEVRIES KEITH MICHAEL DEVRIES KEITH MICHAEL, HAMMEN PHILIP DIETRICH HAMMEN PHILIP DIETRICH
Format Patent
LanguageEnglish
Published 28.03.2001
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides novel processes for preparing 3(S)- (5-chloro-1H-indole-2-carbonyl)-amino­-2(R)-hydroxy-4-phenyl-butyric acid. Also provided are novel intermediates used in those processes. Further, the 3(S)- (5-chloro-1H-indole-2-carbonyl)-amino­-2(R)-hydroxy-4-phenyl-butyric acid prepared by the novel processes can be further reacted to yield known indole 2-carboxamides and derivatives thereof possessing glycogen phosphorylase inhibitory activity, which are useful in the treatment of mammals, especially human beings, having glycogen phosphorylase dependent diseases or conditions.
Bibliography:Application Number: HUP0002285