METHOD FOR PRODUCING ALPHA-FLUOROACRYLIC ACID ESTER

• Main Authors: Gotou, Akihiro, ISHIHARA, Sumi, Komatsu, Yuzo, Yamamoto, Akinori, Kishikawa, Yousuke, Yamamoto, Yoshihiro, Kuroki, Yoshichika, Ohtsuka, Tatsuya
• Format: Patent
• Language: English; Hungarian
• Published: 28.03.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The object of the present invention is to provide a process for producing α-fluoroacrylic acid ester at a high starting material conversion, high selectivity, and high yield. The present invention provides a process for producing the compound represented by the formula (1) wherein R represents alkyl optionally substituted with one or more fluorine atoms, the process comprising step A of reacting a compound represented by the formula (2) wherein X represents a bromine atom or a chlorine atom with an alcohol represented by the formula (3) wherein the symbol is as defined above, and carbon monoxide in the presence of a transition metal catalyst and a base to thereby obtain the compound represented by the formula (1).         R - O H     (3)