PROCESS FOR THE PREPARATION OF CARBOPROST AND ITS TROMETHAMINE SALT

The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are se...

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Main Authors HORTOBAGYI, Iren, LASZLOFI, Istvan, KARDOS, Zsuzsanna, JUHASZ, Imre, VARADI, Csaba, FONAGY, Laszlo, NAGYNE BORKO, Agnes, BUZDER-LANTOS, Peter
Format Patent
LanguageEnglish
Hungarian
Published 28.01.2021
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Summary:The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silicagel chromatography and the salt formation is carried out by using solid tromethamine base.
Bibliography:Application Number: HUE16810011