Multivalent antigen-binding Fv molecule

In one aspect, the present invention relates to an antigen-binding molecule comprising two polypeptide chains, each polypeptide chain having at least four variable domains in an orientation preventing Fv formation and the two polypeptide chains are dimerized with one another thereby forming a multiv...

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Bibliographic Details
Main Authors Le Gall, Fabrice, Little, Melvyn
Format Patent
LanguageEnglish
Hungarian
Published 28.05.2019
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:In one aspect, the present invention relates to an antigen-binding molecule comprising two polypeptide chains, each polypeptide chain having at least four variable domains in an orientation preventing Fv formation and the two polypeptide chains are dimerized with one another thereby forming a multivalent antigen-binding molecule. On each of the two polypeptide chains the four variable domains are arranged in the order V L A-V H B-V L B-V H A from the N-terminal to the C-terminal of the polypeptide.. Compositions of the antigen-binding molecule and the methods of using the antigen-binding molecule or the compositions thereof for treatment of various diseases are also provided herein.
Bibliography:Application Number: HUE11156113