ASSISTED PARTICLE SIZE REDUCTION PROCESS

A new scalable process to control the particle size and the particle size distribution, comprising 5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging;...

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Bibliographic Details
Main Authors COSTA, Eunice, CACELA, Constança, TEMTEM, Marcio, VILLAX, Peter, SOBRAL, Luis
Format Patent
LanguageEnglish
Hungarian
Published 28.05.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A new scalable process to control the particle size and the particle size distribution, comprising 5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (iv) stopping the aging by solvent removal; and (v) optionally, a step of isolating the processed ingredients in the form of powder.
Bibliography:Application Number: HUE15702834