RESOLUTION PROCESS FOR (R)-(-)-2-HYDROXY-2-(2-CHLOROPHENYL) ACETIC ACID

Preparation of (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid (A) comprises resolution of racemic 2-hydroxy-2-(2-chlorophenyl)acetic acid with a substituted amine, as a resolving agent. Preparation of (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid (A) comprises resolution of racemic 2-hydroxy-2-(2...

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Main Authors SUBA, CHARLES, CSATARINE NAGY MARIANNA, DOMBRADY ZSOLT, FOGASSY ELEMER, BALINT JOZSEF, GAJARY ANTAL
Format Patent
LanguageEnglish
Hungarian
Published 30.12.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Preparation of (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid (A) comprises resolution of racemic 2-hydroxy-2-(2-chlorophenyl)acetic acid with a substituted amine, as a resolving agent. Preparation of (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid (A) comprises resolution of racemic 2-hydroxy-2-(2-chlorophenyl)acetic acid (I) with a substituted amine of formula R 2>-CH(R 3>)-CH(NH 2)-R 1> (II), as a resolving agent. R 1>hydroxy-methyl or carbonyl; R 2>phenyl, nitrophenyl or 1-4C alkyl substituted with an amino; R 3>H or OH. Independent claims are also included for: (a) (1S,2S)-(+)-1-phenyl-2-amino-1,3-propanediole (S)-(+)-2-hydroxy-2-(2-chlorophenyl)acetic acid salt; (b) (1R,2R)-treo-(-)-1-(4-nitrophenyl)-2-amino-1,3-propanediole (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid salt; and (c) (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid-L-(+)-lysine salt.
Bibliography:Application Number: HUP0401404