PROCESS FOR THE PREPARATION OF 1-(3,4-DIMETHOXY-PHENYL)-5-ETHYL-7,8-DIMETHOXY-4-METHYL-5H-2,3-BENZODIAZEPINE WITH HIGH PURITY

The present invention relates to the process for the preparation of 1-(3,4-dimethoxy-phenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine of the Formula (I) by reacting 3,4,3',4'-tetramethoxy-6-(a-aceto-propyl)-benzofenon of the general Formula (II) with hydrazine or hydrazine-hydr...

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Bibliographic Details
Main Authors CLEMENTIS GYOERGY DR, HAMORI CSABA, SLEGEL PETER DR, JURAK FERENC DR, RUNGE ZSOLT
Format Patent
LanguageEnglish
Published 28.02.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to the process for the preparation of 1-(3,4-dimethoxy-phenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine of the Formula (I) by reacting 3,4,3',4'-tetramethoxy-6-(a-aceto-propyl)-benzofenon of the general Formula (II) with hydrazine or hydrazine-hydrate in alcoholic medium, and isolating and purifying the reaction product with a clarifier, which comprises using during the clarifying step a recrystallization solution having an iron content lower than 7 ppm.
Bibliography:Application Number: HUP0800399