PROCESS FOR PREPARATION OF SIMVASTATIN AND DERIVATIVES THEREOF

A process for the preparation of compounds of formula (I)whereinR is a C1 to C12 alkyl group andR1 is a protecting group or Hwhich process comprises(a) converting the diol lactone of formula (II)to the protected diol lactone of formula (IIa) wherein R1 is a protecting group(b) acylating the protecte...

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Bibliographic Details
Main Authors STIMAC, ANTON, ZUPANCIC, SILVO, GNIDOVEC, JOZE
Format Patent
LanguageEnglish
Published 28.06.2012
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A process for the preparation of compounds of formula (I)whereinR is a C1 to C12 alkyl group andR1 is a protecting group or Hwhich process comprises(a) converting the diol lactone of formula (II)to the protected diol lactone of formula (IIa) wherein R1 is a protecting group(b) acylating the protected diol lactone (IIa) to give compound (I) wherein R1 is a protecting group,(c) optionally removing the protecting group R1 to give compound (I) wherein R1 is H; andwherein steps (a) and/or (b) are carried out in the presence of N-methylimidazole.
Bibliography:Application Number: HUP0100743