4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.

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Bibliographic Details
Main Authors KANG, SEON HWA, HA, JUN-YONG, LEE, KI-WHA, MOH, JOO HYUN, LIM, KYUNG MIN, CHOI, JIN KYU, YI, JUNG BUM, JEONG, YEON SU, KIM, JIN KWAN, CHUNG, SHIN, BYUN, YOUNG JOO, CHOI, YOUNG HOON, NOH, MIN-SOO, KIM, JI YOUNG, JOO, YUNG HYUP, SHIN, SONG SEOK, LEE, CHANG HOON, PARK, YOUNG-HO
Format Patent
LanguageEnglish
Published 29.05.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.
Bibliography:Application Number: HUP0200623